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| Agent Muriel Green | Successfully complete "The Den of Souls" on the Hard difficulty setting |
| Antadurunnu | Successfully complete "The God Seal" on the Hard difficulty setting |
| Arnold Leech | Successfully complete "Al Khali" on the Easy or Normal difficulty setting |
| Bishop Malthus St. Claire | Successfully complete "Crusades" on the Easy or Normal difficulty setting |
| Blind Behemoth | Successfully complete "Morituri te salutant" on the Hard difficulty setting without being incapacitated |
| Brother William of Auxere | Successfully complete "Motley Crew" on the Hard difficulty setting |
| Centurion Textius Longinus | Successfully complete "Decadence" on the Hard difficulty setting without being incapacitated |
| Child Crusader | Successfully complete "Crusades" on the Easy or Normal difficulty setting |
| Corpses Behemoth | Successfully complete "River of Blood" on the Hard difficulty setting |
| Cpl. Simone Cole | Successfully complete "The Tomb" on the Hard difficulty setting |
| Cpt. Devin Ross | Kill 50 enemies using melee attacks |
| Cpt. Xavier Jones | Successfully complete "Man Down" on the Hard difficulty setting |
| Crossbowman Crusader | Successfully complete "Tortured Souls" on the Hard difficulty setting |
| Cultist | Kill 100 enemies using melee attacks |
| Deceased Devin Ross | Successfully complete "Still With You" on the Hard difficulty setting |
| Enlil | Successfully complete "Spiritual Guide" on the Hard difficulty setting |
| Exlposive Cultist | Disintegrate 50 enemies |
| Flamethrower | Disintegrate 100 enemies |
| Fr. Paul Rawlings | Pop 100 heads |
| Gladiator | Successfully complete "Temple of Pain" on the Hard difficulty setting |
| Governor Cassus Vicus | Successfully complete "Rome" on the Easy or Normal difficulty setting |
| Grenadier | Kill 100 enemies using Ghost Bullet |
| Inanna | Successfully complete "Skin" on the Hard difficulty setting |
| Ki | Successfully complete "Flesh" on the Hard difficulty setting |
| Legionary | Successfully complete "The Low Road" on the Hard difficulty setting |
| Lt. Abigail Black | Kill 50 enemies using Ghost Bullet |
| Nanna | Successfully complete "Blood" on the Hard difficulty setting |
| Ninlil | Successfully complete "Skin" on the Hard difficulty setting without being incapacitated |
| Operation: Godseal | Successfully complete "Exorcism" on the Hard difficulty setting |
| Psychic Commander | Successfully complete "World War 2" on the Easy or Normal difficulty setting |
| Pyxis Prima | Successfully complete "Sumeria" on the Easy or Normal difficulty setting |
| Sgt. Frank Delgado | Pop 50 heads |
| Sgt. Wilhelmina "Billie" Church | Successfully complete "Al Khali" on the Hard difficulty setting |
| Sir Richard de Gray | Successfully complete "Out of the Frying Pan" on the Hard difficulty setting |
| Sumerian Puppet | Successfully complete "Flesh" on the Hard difficulty setting without being incapacitated |
| The Jericho Team | Successfully complete "Rivers of Blood" on the Hard difficulty setting without being incapacitated |
| Utu | Successfully complete "Blood" on the Hard difficulty setting without being incapacitated |
| Warrior Crusader | Successfully complete "Sewers" on the Hard difficulty setting |
