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Directed by Suda 51 of Capcom's Production Studio 4, Killer 7 features some of the most mature themes in a videogame to date. Players take control of the wheelchair bound assassin Harman Smith, a man who can conjure up in physical form the seven deadly personalities that exist in his mind. When a terrorist group known as Heaven's Smile threatens the safety of the United States, the government enlists Smith and his assassins to find and kill the man behind the organization.

Killer 7 features extremely stylized cel-shaded graphics and over-the-top gore. Gameplay is a mix of third-person-based exploration and first-person view gun fights.

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